Medicinteknikportalen LABIB

Lunds Tekniska Högskola

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LABIB seminarie: Drug Effect Evaluation during Permanent Atrial Fibrillation using an AV-node model


Frida Sandberg, Biomedicinsk teknik, LTH

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias in clinical practice. The underlying mechanisms of AF are not completely known but are currently subject to intense research. Various strategies for treatment have been proposed but none has been found as optimal for all patients.

The surface ECG reflects the global electrical activity of the heart. Although the local and complex impulse propagation pattern in the atria during AF cannot be studied in detail from the ECG, it offers possibilities for safe and inexpensive monitoring of the cardiac activity. Various aspects of the unorganized atrial activity and the irregular ventricular response during AF can be explored by examination of the ECG signal. Features extracted from the ECG characterizing AF, may be used as a basis for selection of patient therapy and for noninvasive monitoring of the effects of treatment.

This presentation will mainly focus on a model-based approach for analysis of the ventricular response during AF, which is used to evaluate the effect of four different rate control drugs.

Tid: 12.15-13
Plats: E:1406, E-huset, LTH